氧杂杯[2]芳烃[2]三嗪衍生物的合成及其离子识别性能研究
冯腾垒，张小忠，马正月*
(河北大学 药学院 河北省药物质量分析控制重点实验室，河北 保定 071002)
摘要：以间苯二酚、三聚氯氰和(4-羟基苯基)-(吗啉代)甲酮为原料合成了一个新的标题化合物，并经HRMS、1HMNR、13CNMR、IR、UV-Vis等手段确证了其结构。接着利用荧光光谱法分别考察了它对8种阴离子和10种金属离子的识别性能，结果表明标题化合物可以专属性地识别Fe3+，而对其他测试的阴离子和阳离子没有识别作用，同时其他金属离子不影响标题化合物对Fe3+的识别。利用推导的新非线性拟合方程计算得到标题化合物与Fe3+形成配合比和配合常数分别为1:1和3.41×104 mol/L的配合物，并通过核磁共振波谱法初步确证Fe3+是结合在标题化合物的两个三嗪环组成的空腔中。
关键词：氧杂杯[2]芳烃[2]三嗪；离子识别；荧光淬灭；非线性拟合方程
中图分类号： O625 文献标识码：A 文章编号：0258-3283（2018）
Synthesis and Ion Recognition Properties of Novel Tetraoxacalix[2]arene[2]triazine Derivative FENG Teng-lei, ZHANG Xiao-zhong, MA Zheng-yue⃰ (Key laboratory of Drug Quality Control of Hebei Province, College of Pharmaceutical Science, Hebei University, Baoding 071002, China), Huaxue Shiji, 2018, 40(1)
Abstract：A new tetraoxacalix[2]arene[2]triazine derivative was synthesized by using resorcinol, cyanuric chloride and (4-hydroxyphenyl)-(morpholino) methanoneas raw materials, and the structure was confirmed by HRMS, 1HMNR, 13CNMR, infrared spectrum and UV-spectrum. Moreover the ion recognition property of the compound to eight anions and ten metal cations was separately investigated by fluorescence spectra. The experimental results showed that the obvious fluorescence quenching of the compound had been observed, when Fe3+ was added to the acetonitrile solution, but the fluorescence quenching phenomenon did not appear, when other ions were added to that of the compound, and the other metal ions did not also affect the fluorescence quenching caused by Fe3+. So Fe3+ can be selectively recognized by the compound. The stoichiometric ratio and association constant of the complex between Fe3+ and compound were determined as 1:1 and 3.41×104 mol/L by new nonlinear fitting plot. And it was confirmed by 1HNMR that Fe3+ is located in the cavity formed by two triazzines of the compound.
Key words：tetraoxacalix[2]arene[2]triazine; ion recognition; fluorescence spectroscopy; nonlinear fitting plot
新型含Ni的中温多元金属氧化物脱硝催化剂的合成、表征及催化活性测试
张丹1，姜英男*2，李云飞3，张赩1，孟宪超1，孙晔1，孙伟义*2
( 1. 国网吉林省电力科学研究院，吉林 长春 130021；2. 长春中医药大学 研发中心，吉林 长春 130117；3. 吉林省环境保护厅，吉林 长春 130033 )
摘要：以锐钛矿型TiO2白色粉末为载体，Fe、Ce、Mn、Ni这4种水溶性盐为反应组分，通过一步共沉淀法，制备出一种新型含Ni的中温选择性催化还原(Selective catalytic reduction，SCR)脱硝催化剂——Fe2O3-CeO2-MnOx-NiO/TiO2多元金属氧化物。通过X-射线光电子能谱仪（XPS）、扫描电镜（SEM）、比表面积及孔径测定仪（BET）、X-射线能谱仪（EDS）、X-射线衍射仪（XRD）和热重分析仪（TG）对催化剂进行多种性能表征分析，同时进行脱硝活性测试。结果表明，在脱硝催化中段温度（200 ～ 300 ℃）区间内，制备的新型Fe2O3-CeO2-MnOx-NiO/TiO2多元金属氧化物催化剂表现出良好而稳定的脱硝性能，最高可达90%以上。
关键词：含Ni；多元金属氧化物；SCR脱硝；中温催化
中图分类号：O614 文献标识码：A 文章编号：0258-3283（2017）
Synthesi and Catalytic Activity of New-type Medium Temperature Multi-metal Oxide Catalyst Containing Ni ZHANG Dan1, JIANG Ying-nan*2, LI Yun-fei3, ZHANG Xi1, MENG Xian-chao1, SUN Ye1, SUN Wei-yi*2(1. State Grid Jilin Electric Power Research Institute, Changchun 130021, China; 2. Changchun University of Chinese Medicine, Changchun 130117, China; 3. Enviromental Protection Department of Jilin Province, Changchun 130033, China), Huaxue Shiji, 2017, 39(12)
Abstract: With anatase TiO2 white powder as the carrier, Fe, Ce, Mn and Ni four kinds of water soluble salts as reactive components, a new-type medium temperature selective catalytic (selective catalytic reduction, SCR) denitration catalyst Fe2O3-CeO2-MnOx-NiO/TiO2 multi-metal oxide has been prepared by one-step coprecipitation method. X-Ray photoelectron spectroscopy (XPS), scanning electron microscop (SEM), energy dispersive spectrometer (EDS), N2 adsorption instrument (BET), X-ray diffraction(XRD) and thermogravimetric analysis(TG) were carried to characterize the performance of the catalyst. Meanwhile, the important denitration activity test has been simulated on the prepared multi-metal oxide catalyst. The result proved that the prepared new-type Fe2O3-CeO2-MnOx-NiO/TiO2 multi-metal oxide catalyst exhibited well denitrification performance, in the medium temperature range from 200 to 300 ℃. The catalytic denitrification efficiency is up to 90% and more, with a stable and broad temperature range.
Key words: containing Ni; multi-metal oxide catalyst; SCR denitration; catalytic activity in medium temperature
新型抗心绞痛药物的设计、合成及生物活性的评价
张阳1，许勤龙2，李家明*1，林高峰2，郭敬2，李昌文3
(1.安徽中医药大学 药学院，安徽 合肥 230038； 2. 合肥医工医药有限公司，安徽 合肥 231200；
3. 安徽丰原药业股份有限公司淮海药厂，安徽 蚌埠 233705)
摘要：以雷诺嗪为模板，设计合成了3个雷诺嗪类似物，其结构经1HNMR、13CNMR、ESI-MS确证。考察所合成化合物对大鼠心绞痛模型ST-T波、CK-MB、MDA、LDH的影响。结果显示，所合成化合物能显著抑制大鼠心绞痛模型ST-T波抬高，并能降低大鼠心绞痛模型MDA、LDH、CK-MB的含量，优于阳性对照物雷诺嗪。所合成化合物具有显著的抗心绞痛、心肌损伤保护作用，具有较好的开发前景。
关键词：雷诺嗪；雷诺嗪类似物；抗心绞痛
中图分类号：R916 文献标识码：A 文章编号：0258-3283（2018）
Design, Synthesis and Biological Evaluation of the Novel Anti-angina Drugs ZHANG Yang1, XU Qin-long2, LI Jia-ming*1, LIN Gao-feng2, GUO Jing2, LI Chang-wen3(1. College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230038, China; 2. Hefei Industrial Medical Pharmaceutical Institute Co., Ltd., Hefei 231200, China; 3.Huaihai Pharmaceutical Factory of Feng yuan Pharmaceutical Co., Ltd, Bengbu 233705, China), Huaxue Shiji, 2018, 40(1)
Abstract: Using ranolazine as the template, three ranolazine analogues were designed and synthesized, and the structures were confirmed by 1HNMR,13CNMR and MS. Detecting the effects of synthetic compounds on ST-T wave, CK-MB, MDA and LDH in rat angina pectoris model. The results showed that, synthetic compounds can significantly inhibit the elevation of ST-T wave and decrease the content of MDA, LDH and CK-MB in rats with angina pectoris, which is superior to that of ranolazine. The synthetic compounds have significant anti-angina pectoris, myocardial injury protection, with good prospects for development.
Key words: Ranolazine; Ranolazine analogues; angina pectoris
茶碱并四唑类衍生物的设计合成以及抗惊厥活性的研究
全殷晟，金光浩，尹秀梅*，全哲山
(延边大学 药学院 药物化学教研室，吉林 延吉 133002)
摘要：寻找高效的潜在抗癫痫药物，设计合成系列目标化合物并测定其抗惊厥活性。以8-氯茶碱为起始原料，经取代、肼代和环合3步反应合成目标化合物，并采用最大电惊厥法对所合成化合物进行抗惊厥活性的测定。所有合成化合物结构经1HNMR和13CNMR进行确证。其中，4-正壬烷-6, 8-二甲基-4H-苯并[4, 5]咪唑并[1, 2-d]四唑-5, 7(6H, 8H)-二酮的抗惊厥活性最强，其ED50为22.38 mg/kg，具有潜在的抗癫痫活性。
关键词：茶碱；四唑；合成；抗惊厥活性；最大电惊厥
中图分类号：R914.5 文献标识码：A 文章编号：0258-3283（2018）
Design, Synthesis and Anticonvulsant Evaluation of Theophylline Containing TetrazoleDerivates QUAN Yin-sheng, JIN Guang-hao, YIN Xiu-mei*, QUAN Zhe-shan (Department of Medicinal Chemistry, College of Pharmacy, Yanbian University, Yanji 133002, China), HuaxueShiji, 2018, 40(1)
Abstract: Objective Searching for novel high efficiency anticonvulsant active substances, a series of 4-substituted-6,8-dimethyl-4H-benzo[4,5]imidazo[1,2-d]tetrazole-5,7(6H,8H)-dione derivatives were designed, synthesized and evaluated for their anticonvulsant activity.8-Chloro-1,3-dimethyl-2,6-(1H,3H)-purinedione as a starting material,the target compounds 4-substituted-6,8-dimethyl-4H-benzo[4,5]imidazo[1,2-d]tetrazole-5,7(6H,8H)-dione derivatives were prepared via displacement reaction and cyclization reaction, and their anticonvulsant activity were investigated by the maximal electroshock seizure. The structures of synthesized compounds were confirmed by 1HNMR and 13CNMR. The compound 4-nonyl-6,8-dimethyl-4H-benzo[4,5]imidazo[1,2-d]tetrazole-5,7(6H,8H)-dioneshowed the most anticonvulsant activity with ED50 values of 22.38 mg/kg, as a potential antiepileptic activity.
Key words: theophylline; tetrazole; synthesis; anticonvulsant activity; maximal electroshock seizure
苯偶酰衍生物的合成及紫外吸收性能和光稳定性能研究
王志刚，王治国*
（湖北理工学院 化学与化工学院 矿区环境污染控制与修复湖北省重点实验室，湖北 黄石 435003）
摘要：以酚醚和草酰氯为原料，经Friedel-Crafts酰基化反应来制得一系列苯偶酰类化合物，并通过1HNMR、13CNMR对目标产物进行结构表征。同时还考查了8种苯偶酰类化合物的紫外吸收性能和光稳定性能。结果表明，化合物III1 ~ III8对UVB具有良好的吸收性能，而且化合物III1和化合物III6兼具对长波紫外线UVA和中波紫外线UVB的吸收性能。化合物III1 ~ III8的光稳定性顺序为化合物III1>化合物III8>化合物III5>化合物III7>化合物III4>化合物III2>化合物III3>化合物III6。
关键词：苯偶酰；紫外吸收；光稳定性
中图分类号：R914.5 文献标识码：A 文章编号：0258-3283（2017）
Synthesis, Ultraviolet Absorption Characteristics and Light Stabilities of Benzoyl Derivatives WANG Zhi-gang, WANG Zhi-guo*(Hubei Key Laboratory of Mine Environmental Pollution Control & Remediation, School of Chemical and Materials Engineering, Hubei Polytechnic University, Huangshi 435003, China), Huaxue Shiji, 2017, 39(12)
Abstract: A series of benzoyl compounds were obtained by Friedel-Crafts acylation using phenol ether and oxalylchloride as starting materials. The structures of the target products were confirmed by means of 1HNMR, 13CNMR and their ultraviolet absorption characteristics and light stabilities were also investigated. The results showed that compounds III1 ~ III8exhibit good absorbency as the UV-B-type absorbents, and compounds III1 and III6 both functions as long-wave ultraviolet (UVA) and medium-wave ultraviolet (UVB) absorbents. The stability order of compounds III1 ~ III8 is III1>III8>III5>III7>III4>III2>III3>III6.
Key words: benzoylderivatives; ultraviolet absorption; light stability
1-取代苯基-5-三氟甲基（二氟甲基）-4-吡唑甲酸的合成研究
鲍志远，黄苇静，宋涵博，黄家兴*
(中国农业大学 理学院 应用化学系化学试剂研发平台，北京 100193)
摘要：对标题化合物的合成工艺进行了研究改进。以苯肼盐酸盐为原料，经中和、干燥之后与2-乙氧基亚甲基-4,4,4-三氟（-4,4-二氟）乙酰乙酸乙酯在四氢呋喃中关环。相比于文献中在质子溶剂或有水存在下的关环条件，本工艺可以高选择性地得到1-取代苯基-5-三氟甲基（二氟甲基）吡唑-4-甲酸乙酯。所得产物再经水解共得到20个目标产物，结构经1HNMR、13CNMR、HRMS确证。
关键词：1-取代苯基-5-三氟甲基-4-吡唑甲酸；1-取代苯基-5-二氟甲基-4-吡唑甲酸；吡唑酸；合成
中图分类号：0626.2 文献标识码：A 文章编号：0258-3283（2018）
Synthesis of 5-Trifluoromethyl (difluoromethyl) -1-phenyl- 1H-pyrazole-4-carboxylic Acid BAO Zhi-yuan, HUANG Wei-jing, SONG Han-bo, HUANG Jia-xing*( , College of Sciences, China Agricultural University, BeiJing 100193, China), Huaxue Shiji, 2018, 40(1)
Abstract: In this work, the synthetic procedure of 1- substitutedphenyl-5- trifluoromethyl(difluoromethyl) -1- phenyl-1H -pyrazole-4-carboxylic acid was investigated. Using phenylhydrazine hydrochloride as raw material. After neutralization, drying or dehydration of water, on reaction with 2- ethoxymethylene 4,4,4-trifluoromethyl (4,4- difluoromethyl) ethyl acetoacetate in THF the pyrazole ring formed with good region selectivity compared with the reaction conditions in the presence of proton solvent or water in the previous literature. The resulting products were then hydrolyzed to yield the target products. A total of 20 target compounds were synthesized which were confirmed by 1HNMR, 13CNMR and HRMS.
Key words: 5-trifluoromethyl (triifluoromethyl)-1-phenyl-1H-pyrazole-4- carboxylic acid; 5-trifluoromethyl (difluoromethyl) -1-phenyl-1H -pyrazole-4- carboxylic acid; pyrazole-4- carboxylic acid; synthesis
氯霉胺类催化剂在有机反应中的应用研究进展
徐蒙蒙1，徐嘉琪1，张奇1，尹祥健2，杨鸿均*1，冯豫川1，曾碧涛3
(1. 西南民族大学 化学与环境保护工程学院，四川 成都 610041；2. 四川川大华西药业股份有限公司 四川 成都 610014；3. 宜宾职业技术学院 五粮液技术学院 四川 宜宾 44003)
摘要：(1S,2S)-1-(4-硝基苯基)-2-氨基-1,3-丙二醇俗称氯霉胺，是工业生产氯霉素的副产物，廉价易得，且其结构具有两个手中心，并含有两个羟基和一个氨基，易被改造和修饰，其衍生物可以作为小分子催化剂。氯霉胺结构中的氮原子与氧原子有很好的配位能力，可与多种金属进行配位参与许多不对称催化反应。围绕氯霉胺及其衍生物作为手性催化剂在不对称催化反应中的应用进展做系统的综述。
关键词：氯霉胺；衍生物；手性催化剂；不对称催化反应
中图分类号： 文献标识码：A 文章编号：0258-3283（2018）
Progressof Chiral Chloramphenicol Base Catalystsin Organic Synthesis XU Meng-meng1, XU Jia-qi1, ZHANG Qi1, YIN Xiang-jian2, YANG Hong-jun*1, FENG Yu-chuan1, ZENG Bi-tao3(1. College of Chemistry and Environment Protection Engineering, Southwest MinZu University, Chengdu 610041, China; 2. Sichuan chuanda West China Pharmaceutical Co., Ltd., Chengdu 610014, China; 3. School of Wuliangye Technology, Yibin Vocational and Technical College, Yibin 644003, China), Huaxue Shiji, 2018, 40(1)
Abstract: The commercially available (1S, 2S)-2-amino-1-(p-nitrophenyl)-propane-1,3-diol(chloramphenicol base), which is a by-product in the industrial production of chloramphenicol. The structure of chloramphenicol base contains two chiral centers, and its two hydroxyl groups and an amino group can be easily modified. The nitrogen atom and oxygen atom in chloramphenicol base has a good coordination ability with a variety of metal ions. So its derivatives employed as chiral catalysts and chiral ligands in organic reactions. This work summarizes chloramphenicol base act as chiral catalysts was employed in various asymmetric reactions .
Key words：chloramphenicol base; derivatives; chiral catalyst; asymmetric reactions
β-三氟甲基-β-氨基酸及其衍生物的合成研究进展
李成林，李振，布仁，马宇衡*，云学英*
（内蒙古医科大学 药学院，内蒙古 呼和浩特 010110）
摘要：β-三氟甲基-β-氨基酸及其衍生物具有独特的药理活性和潜在的药学应用价值，在药物设计中用于提高药物活性或改善药代动力学特性。因此，其合成受到药物化学家和有机化学家们越来越多的关注。重点介绍近年来β-三氟甲基-β-氨基酸及其衍生物的合成方法。
关键词：β-三氟甲基-β-氨基酸；合成；药物活性
中图分类号：O621.3 文献标识码：A 文章编号：0258-3283（2017）
Progress in Synthesis of β-Trifluoromethyl β-Amino Acid and Its Derivatives LI Cheng-lin, LI Zhen, BU Ren, MA Yu-heng*, YUN Xue-ying*(School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China), Huaxue Shiji, 2017, 39(12)
Abstract: β-Trifluoromethyl β-amino acid and its derivatives have unique pharmacological activity and potency, which are used in drug design to improve drug activity or pharmacokinetic properties. And now, the development of efficient synthetic methods is of considerable interest in academia and industry. This work focuses on the synthesis of β-trifluoromethyl β-amino acid and its derivatives in recent years.
Key words: β-trifluoromethyl β-amino acid; synthesis; pharmacological activity
邻菲罗啉示差分光光度法测定铁矿石中全铁含量
吴永明，陶武*，黄飞雪，陈学娟，钟广蓉
（北京科技大学 化学分析中心，北京 100083）
摘要：选择了4个铁矿石标样，分别用三氯化钛还原重铬酸钾滴定和邻菲罗啉示差分光光度法测定其中的全铁含量。实验结果显示，加入5 mL（15 g/L）抗坏血酸和5 mL(6 g/L)邻菲罗啉溶液，以0.6 mg Fe作为参比，测定铁溶液的吸光度，作工作曲线。结果发现，Fe的含量在0.8 ～1.6 mg时，其Fe的质量与吸光度之间具有很好的线性关系。在此条件下，对4个铁矿石标样做了6次平行测定，测定结果与标准值误差较小，RSD< 0.92%（n = 6），加标回收率为91.0% ～ 107%。通过F检验和t检验得知，测得结果与标准值间不存在显著性差异，该方法与三氯化钛还原重铬酸钾滴定法之间不存在显著性差异（置信度95%）。
关键词：铁矿石；全铁；邻菲罗啉；分光光度法；滴定法
中图分类号：O655 文献标识码：A 文章编号：0258-3283（2017）
Measurement of Total Iron Content in Iron Ore by Phenanthroline Spectrophotometry WU Yong-ming, TAO Wu*, HUANG Fei-xue, CHEN Xue-juan, ZHONG Guang-rong (Center of Chemical Analysis, University of Science and Technology Beijing, Beijing 100083, China), Huaxue Shiji, 2017, 39(12)
Abstract: Total iron content in four iron ore samples were measured by titanium trichloride reduction potassium dichromate titration and phenanthroline spectrophotometric method. The results show that, there was a good linear relationship between the mass and the absorbance of iron when the content of iron was between 0.8-1.6 mg, after adding 5 mL(15 g/L) ascorbic acid and 15 mL(6 g/L) phenanthroline acid, and the absorbance of iron solution was measured with 0.6 mg iron as reference. The total iron content in four iron ore samples were determined for 6 times. The relative error of tested result and theoretical value was small, and the relative standard deviation(RSD, n = 6) was not more than 0.92%. The standard addition recovery was 91.0% ～ 107%. Through the F-test and t-test, the result showed that there was no significant differences between the results and the standard values, and there was no significant difference between titanium trichloride reduction potassium dichromate titration and phenanthroline spectrophotometric method (95% confidence level).
Key words: iron ore; total iron; phenanthroline; spectrophotometry; titrimetry.
敌百虫-D6在土壤农残检测中的应用
王静茹1, 2，李美华2，陈东辉1，徐静安2，罗勇*2
(1. 上海应用技术大学 化学与环境工程学院，上海 201418；2. 上海化工研究院有限公司，上海 200062)
摘要：以自制的敌百虫-D6为内标，采用均匀设计的实验方法优化固相萃取条件，建立了土壤中敌百虫的高效液相色谱-串联四极杆质谱的测定方法。本方法的前处理采用GCB/NH2固相萃取柱，以V (乙腈)∶V (甲苯) ＝ 3∶1为洗脱剂、丙酮为提取液，以Thermo Hypersil GOLD色谱柱为分离柱、V (甲醇)∶V (0.1%甲酸水) ＝ 80∶20为流动相，并在电喷雾正离子的选择反应监测模式下进行检测。本方法的检出限为0.05 mg/kg，线性范围为0.1 ～ 10 µg/mL，加标回收率为96.0% ～ 103.8%，相对标准偏差(RSDs)为1.0% ～ 2.7%。
关键词：敌百虫-D6；稳定同位素内标；均匀设计；土壤
中图分类号：O657.63 文献标识码：A 文章编号：0258-3283(2017)
Applications of Trichlorfon-D6 in the Determination of Pesticides Residues in Soil WANG Jing-ru1, 2, LI Mei-hua2, CHEN Dong-hui1, XU Jing-an2, LUO Yong*2(1. School of Chemical and Environmental Engineering, Shanghai Institution of Technology, Shanghai 201418, China; 2. Shanghai Research Institute of Chemical Industry Co., Ltd, Shanghai 200062, China), Huaxue Shiji, 2017, 39(12)
Abstract: A method for the determination of pesticides residues in soil was developed by liquid chromatography-tandem mass spectrometry (LC-MS-MS) with self-prepared trichlorfon-D6 as internal standard, and the conditions of solid phase extraction was optimized via uniform design. The sample pretreatment adopted GCB/NH2 solid phase extraction cartridge with V (acetonitrile)∶V (methylbenzene)＝3∶1 as eluent, acetone as extractant. Chromatographic separation was carried out using the thermohypersil GOLD separation column with the mobile phase of V (methyl alcohol)∶V (0.1% formic acid water)＝80∶20 and determined in the positive mode of SRM. The limit of detection was 0.05 mg/kg with the linear range 0.1 ～ 10 µg/mL, recovery rates 96.0% ～ 103.8%, and RSDs 1.0% ～ 2.7%.
Key words: trichlorfon-D6; stable isotope internal standard; uniform design; soil
敞开消解-ICP-OES同时测定地球化学样品中硫、磷、砷、硼
王佳翰，汤凯，龙军桥，王达成，张亚峰*
（中国人民武装警察部队黄金第九支队化验室，海南 海口 571127）
摘要：建立了敞开消解-ICP-OES同时测定地球化学样品中非金属元素硫、磷、砷、硼的方法。采用硝酸、氢氟酸、高氯酸体系消解地球化学样品，并加入甘露醇固定B，ICP-OES同时测定非金属元素S、P、As、B。经反复实验，确定了甘露醇的最佳加入量为1 mL；最佳消解温度为140 ℃；最佳谱线为As 189.042 nm、P 178.284 nm、S 182.034 nm、B 208.959 nm，并使用Se内标进行漂移补偿。结果表明，S、P、As、B检出限分别为12、4.2、5.8、7.0 μg/g，平均相对标准偏差分别为5.7%、2.1%、3.8%、4.7%（n = 11），4种元素加标回收率在89% ～ 110%之间（n = 6），且标准物质分析结果与认定值较为接近，说明本法分析化探样品准确可靠。
关键词：敞开消解；地球化学样品；非金属元素；ICP-OES
中图分类号：O657.3 文献标识码：A 文章编号：0258-3283（2017）
Simultaneous Determination of Sulfur, Phosphorus, Arsenic and Boron in Geochemical Samples by ICP-OES with Open Digestion WANG Jia-han, TANG Kai, LONG Jun-qiao, WANG Da-cheng, ZHANG Ya-feng*（No.9 Geological Part of CAPF, Haikou 571127, China）, Huaxue Shiji, 2017, 39(12)
Abstract: A method for simultaneous determination of nonmetal elements such as sulfur, phosphorus, arsenic and boron in geochemical samples by ICP-OES with open digestion was established. The geochemical samples were digested with nitric acid, hydrofluoric acid and perchloric acid, and the mannitol was added to fix boron. The optimum amount of mannitol was 1 mL, the optimum digestion temperature was 140 ℃, and the optimum analytical spectral line was As 189.042 nm, P 178.284 nm, S 182.034 nm and B 208.959 nm, respectively. Se was used to drift compensation as internal standard. The results showed that detection limit of S, P, As, B was 12, 4.2, 5.8, 7.0 μg/g, respectively. The relative standard deviation(RSD)was 5.7%, 2.1%, 3.8% and 4.7% respectively (n = 11), the recovery of four elements was between 89% ~ 110% (n = 6), and the measured value was close to the certified value of certified reference material, it showed that this method was accurate and reliable to analysis of geochemical samples.
Key words: open digestion; geochemical samples; nonmetal elements; ICP-OES
高效液相色谱-质谱法测定车用清洗剂中烷基酚聚氧乙烯醚
高俊伟*，叶平，谢坚，汶海花，朱磊
(泰州市产品质量监督检验中心，江苏 泰州 225300)
摘要：建立了一种用于检测车用清洗剂中烷基酚聚氧乙烯醚的高效液相色谱-质谱法。流动相采用5 mmol/L乙酸铵水溶液和甲醇混合溶液，采用梯度淋洗模式，色谱柱柱温为40 ℃，流速为0.3 mL/min，进样量为10 µL，质谱检测器为电喷雾离子源（ESI），采用选择离子(SIM)正模式。该法所建立的辛基酚聚氧乙烯醚（OPEO）和壬基酚聚氧乙烯醚(NPEO)的线性范围分别为1.0 ～ 50.0和0.5 ～ 50.0 mg/L，线性系数r均大于0.999，辛基酚聚氧乙烯醚和壬基酚聚氧乙烯醚的方法检出限分别为1.0和0.5 mg/kg，精密度分别为1.46%和2.79%（n = 8），加标回收率分别在80.0% ～ 98.3%和88.5% ～ 100.2%。该方法操作简单、准确、快捷，可用于车用清洗剂中辛基酚聚氧乙烯醚及壬基酚聚氧乙烯醚的定性与定量检测。
关键词：高效液相色谱；质谱；烷基酚聚氧乙烯醚；车用清洗剂
中图分类号：O657.6 文献标识码： A 文章编号：0258-3283（2017）
Determination of Alkylphenol Ethoxylates in Cleaning Agent for Vehicle by High Performance Liquid Chromatography-Mass Spectrometry GAO Jun-wei*, YE Ping, XIE Jian, WEN Hai-hua, ZHU Lei (Product Quality Supervising and Inspecting Center of Taizhou City, Taizhou 225300, China), Huaxue Shiji, 2017, 39(12)
Abstract: A high performance liquid chromatography mass spectrometry (HPLC-MS) method was developed for the determination of alkylphenol ethoxylates in vehicle cleaning agents. The mobile phase was 5 mmol/L ammonium acetate solution and methanol mixed solution by gradient elution mode, column temperature of 40 ℃, the flow rate of 0.3 mL/min, sample volume 10 µL, mass spectrometry using selected ion mode detection (SIM), electrospray ionization (ESI), positive ion mode. Octylphenoxypolyethoxyethanol(OPEO) and nonylphenolethoxylates (NPEO) linear range are respectively 1.0 ～ 50.0 mg/L and 0.5 ～ 50.0 mg/L, the linear coefficient of R was greater than 0.999, the method of octylphenolethoxylates and nonylphenolethoxylates for limit of detections（LOD）were 1.0 and 0.5 mg/kg. The values of RSD were 1.46% and 2.79%, respectively (n = 8). The recoveries were 80.0% ～ 98.3% and 88.5% ～ 100.2%. This method is simple, accurate and rapid. It was used for qualitative and quantitative for vehicle cleaning agent octylphenolethoxylates and nonylphenolethoxylates.
Key words: high performance liquid chromatography；mass spectrometry; alkylphenolethoxylates; cleaning agent for vehicle
荷移反应分光光度测定阿普唑仑
王虹，王军*
（江苏警官学院 刑事科学技术系，江苏 南京 210031）
摘要：研究了阿普唑仑的荷移反应，确定形成电荷转移配合物的最佳反应条件。采用分光光度法测定阿普唑仑的含量，在乙醇溶液中，阿普唑仑与荷移试剂酚酞在30 ℃下反应40 min，形成配比为1 : 2荷转移配合物。该荷转移配合物最大吸收波长为225 nm，线性方程为y = 0.3713 x - 0.0021，相关系数R = 0.9995，相对标准偏差为1.6%，检测溶液在24 h内稳定，与药典的紫外吸收方法的测定结果一致。
关键词：荷移反应；阿普唑仑；酚酞
中图分类号：Ｏ657.32 文献标识码： A 文章编号：0258-3283(2017)
Determination of Alprazolam with Charge Transfer Reaction WANG Hong, WANG Jun*(Department of Forensic Science, Jiangsu Police Institute, Nanjing 210031, China ), Huaxue Shiji, 2017, 39(12)
Abstract：In order to elucidate the effect of alprazolam on the charge transfer reaction and confirm the optimum reaction conditions for the formation of charge transfer complex, aspectrophotometric method for determination of the content of alprazolam was described. Alprazolamreacts with the charge transfer reagent phenolphthalein to form 1:2 complex in 30℃ for 40 min in alcohol solution with maximum absorption at 225 nm. The linear equation was y=0.3713x-0.0021 with relative coefficient 0.9995， and relative standard deviation was 1.6%. The solution was stabled during 24 h，and the method was accurate and has been used in the determination of alprazolam in tablets. The results were in good agreement with the official method， the UV absorb method.
Key words：charge transfer reaction; Alprazolam; phenolphthalein
丙烯酸酯卟啉荧光探针的合成及性能
张晓，王振兴，裴熙林，张学俊*
(中北大学 理学院，山西 太原 030051)
摘要：以5-(4-丙烯酸酯基苯基)-10, 15, 20-三苯基卟啉(APTPP)为荧光增强型探针，对半胱氨酸(Cys)进行特异性检测。以吡咯、苯甲醛、对羟基苯甲醛、丙烯酰氯等原料合成了产物APTPP，并通过红外光谱、核磁共振谱、元素分析等对APTPP结构进行表征，并利用紫外-可见光谱、荧光光谱对其进行性能检测。实验结果表明，APTPP探针对半胱氨酸(Cys)具有特异性选择，半胱氨酸浓度在1.0×10-8 ～ 1.0×10-7 mol/L范围内，△F=4.082+51.60［Cys］(10-7 mol /L)，相关系数R = 0. 9993，检出限为2.2 × 10-9 mol /L。
关键词：卟啉；丙烯酸酯；荧光增强；荧光探针；半胱氨酸
中图分类号：O626 文献标识码：A 文章编号：0258-3283（2018）
Synthesis and Properties of Acrylate Porphyrin Fluorescent Probes ZHANG Xiao, WANG Zhen-xing, PEI Xi-lin, ZHANG Xue-jun*(College of Science, North University of China, Taiyuan 030051, China), Huaxue Shiji, 2018, 40(1)
Abstract: A new type of 5- (4-acrylicester-phenyl)-10,15,20-triphenyl porphyrin (APTPP) was prepared bypyrrole, benzaldehyde, p-hydroxy benzaldehyde and acryloyl chloride. It is used as a fluorescene-enhanced probe for special detection of Cysteine(Cys). The structure of APTPP was confirmed by IR, NMR and elemental analysis. The propertiesof APTPP were measured by UV-Vis spectra and fluorescence spectra. The results indicated that the differential selection of APTPP was performed to Cys. The concentration of Cys was in the range of 1.0×10-8～1.0×10-7 mol/L, with linear equation as △F=4.082+51.60［Cys］(10-7mol/L)and correlationcoefficient as R= 0. 9993. The detection limit for Cys was 2.2 × 10-9mol /L．
Key words: porphyrin; acrylate; fluorescence enhancement; fluorescence probe; cysteine
Mn(mmtz)2(phen)(H2O)2配合物的合成、晶体结构及热性质研究
于慧1，王昌权2，于青2，边贺东*1, 2，刘宝1，黄富平*2
（1. 广西民族大学 化学化工学院 广西林产化学与工程重点实验室，广西 南宁 530008；2. 广西师范大学 化学与药学学院 药用资源化学与药物分子工程国家重点实验室，广西 桂林 541001）
摘要：以5-巯基-1-甲基四唑（Hmmtz）及1, 10-菲罗啉（phen）为原料，与金属Mn(II)盐反应得到一种新的混配配合物Mn(mmtz)2(phen)(H2O)2，并对该化合物进行元素分析、红外光谱、X-射线单晶衍射以及差热-热重等表征。晶体结构分析表明，化合物C16H18MnN10O2S2属单斜晶系，空间群为Cc，晶胞参数为a = 7.7913(13) nm，b = 28.709(3) nm，c = 10.1095(15) nm，α = 90°，β = 111.844(2)°，γ = 90°，V = 2099.0(5) nm3，Z = 4。配合物中的金属锰离子分别与1个1,10-菲罗啉的2个氮原子、2个5-巯基-1-甲基四唑提供的2个氮原子和2个水分子氧配位，形成八面体构型。
关键词：5-巯基-1-甲基四唑；Mn(II)配合物；晶体结构；热稳定性
中图分类号：O614 文献标识码：A 文章编号：0258-3283（2017）
Synthesis, Structure and Thermal Stability Properties of Mn(II) Complex with 5-Mercapto-1-methyltetrazole YU Hui1, WANG Chang-quan2, YU Qing2, BIAN He-dong*1, 2, LIU Bao1, HUANG Fu-ping*2(1. Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530008, China; 2. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541001, China), Huaxue Shiji, 2017, 39(12)
Abstract: The new complex, Mn(mmtz)2(phen)(H2O)2, was synthesized by the solution method using 5-mercapto-1-methyltetrazole(Hmmtz) and 1, 10-phenanthroline(phen). The complex was characterized by elemental analysis, IR, single crystal X-ray and thermogravimetric analysis (TGA). The results of X-ray crystallographic analysis indicate that the complex belongs to monoclinic, space group Cc, unit cell dimensions with a = 7.7913(13) nm, b = 28.709(3) nm, c = 10.1095(15) nm, α = 90°, β = 111.844(2)°, γ = 90°, V = 2099.0(5) nm3, Z = 4. In the complex, Mn(II) ion is coordinated by two N atoms from one phen, two N atoms from the two mmtz anions, and two water molecules.
Key words: 5-mercapto-1-methyltetrazole; Mn(II) complex; crystal structure; thermal stability
GSS471/TX-100复配体系动态表面活性研究
祝霞，喻红梅，华平*
（南通大学 化学化工学院，江苏 南通 226019）
摘要：用最大泡压法测定磺酸盐型双子表面活性剂1, 4-丁二醇双子琥珀酸二仲辛酯磺酸钠（GSS471）与TX-100复配溶液的动态表面张力(DST)，详细表征了DST随时间的变化过程，研究了配比和浓度对其DST的影响，利用Rosen模型得出DST的n、t*、ti、tm和R1/2。结果表明，复配溶液浓度越高，吸附到界面的速率越快，介平衡表面张力值越小且越接近平衡值，DST曲线越低，且扩散势垒越小，吸附势垒越大，动态表面活性越高。当复配溶液形成大量胶束、n(GSS471) : n(TX-100) = 0.4 : 0.6时，动态表面活性最好，且较两单一表面活性剂的动态表面活性显著；当复配溶液形成微量或未形成胶束、配比为n(GSS471) : n(TX-100) = 0.2 : 0.8时，动态表面活性最好。
关键词：琥珀酸酯磺酸盐；双子表面活性剂；复配；动态表面张力；动态表面活性
中图分类号：O647.11 文献标识码：A 文章编号：0258-3283（2017）
Dynamic Surface Activity of GSS471/TX-100 Complex System ZHU Xia, YU Hong-mei, HUA Ping*
(School of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China), Huaxue Shiji, 2018, 40(1)
Abstract：The dynamic surface tensions (DST) of 1,4- butylenebis-secoctylsulfo succinate (GSS471) and TX-100 complex aqueous solutions were investigated using the maximum bubble pressure method, the variation of DST with time is described in detail, the effects of ratio and concentration on DST were investigated, and the characteristic parameters of DST are obtained by using Rosen model, such as n, t*, ti, tm and R1/2.The results showed that，the higher the concentration of mixed solution, the faster the adsorption to the interface, the smaller the medium equilibrium surface tension value and the closer to the equilibrium value, the lower the DST curve, and the smaller the diffusion barrier, the greater the adsorption barrier, the higher the dynamic surface activity. When a large number of micelles were formed in the mixed solution, the dynamic surface activity of n(GSS471) : n(TX-100) = 0.4 : 0.6 was the best and the dynamic surface activity was significantly higher than that of the single surfactant. When the mixed solution was formed in the presence of a small amount or no micelle, the dynamic surface activity was best when the ratio was n(GSS471) : n(TX-100) = 0.2 : 0.8.
Key words：sulfo succinate; gemini surfactant; formulation; dynamic surface tension; dynamic surface activity
银增强共振光散射法测定神经元特异性烯醇化酶
邹明静*1，王娜2，魏彦刚1
（1.菏泽医学专科学校 中心实验室，山东 菏泽 274030；2.商丘高等医学专科学校，河南 商丘 476000）
摘要：采用平均粒径约为15 nm纳米金颗粒标记神经元特异性烯醇化酶抗体（anti-NSE）获得金标记anti-NSE，其与神经元特异性烯醇化酶（NSE）发生特异性免疫反应后生成NSE免疫金复合物，经离心分离后可获得含有金标记anti-NSE的上层清液。以上清液中的纳米金催化银离子还原生成金银复合纳米微粒，该复合纳米微粒在470 nm处具有较强的共振光散射信号。结果表明，NSE 浓度在0. 02 ～ 15.0 ng/mL范围内与共振光散射强度变化值ΔI470nm呈现良好的线性关系，检出限为0.003 ng/mL，用于人血清中NSE的定量分析，测定结果满意。
关键词：纳米金1；神经元特异性烯醇化酶2；金标记3；银增强4；共振光散射5
中图分类号：O656.3 文献标识码：A 文章编号：
Resonance Light Scattering Spectral Assay of Neuron Specific Enolase Based on Silver Staining Enhancement ZOU Ming-jing*1，WANG Na2，WEI Yan-gang1 (1.Central Laboratory, Heze Medical College, Heze 274030, China; 2. Shangqiu Medical College, Shangqiu 476000, China ), Huaxue Shiji, 2018, 40(1)
Abstract: Approximately 15nm gold nanoparticles were modified by neuron specific enolase antibody (anti-NSE) to obtaingold-labeled anti-NSE. Neuron specific enolase (NSE) could conjugate gold-labeling anti-NSE and gold modified NSE immunocomplexes produced in appropriate condition. Then the immunocomplexes were deposited by centrifugation and the upper solution containing gold-labeling anti-NSE left. Gold nanoparticles in the solution were used as nuclei and catalysts to reduce silver ions to metallic silver and deposited at the surface of gold nanoparticles, which resulted in the stronger resonance light scattering signals at 470nm. The results showed thatΔI470nmhad a good linear relationship with NSE in the range from 0. 02 ng/mL to 15.0 ng/mL and the detection limit was 0.003 ng/mL. It was used for the quantitative detecting of NSE in the serum with satisfactory results.
Key words: gold nanoparticles; neuron specific enolase; gold labeling; silver staining enhancement; resonance light scattering
一种新型Zn-MOF配合物在荧光检测水体金属离子中的
应用研究
周勇*，杨怡，朱肖
（常州工程职业技术学院 科技处，江苏 常州 213164）
摘要：研究以一种水稳定性良好的新型二维Zn-MOF配合物为荧光探针来检测水体中金属离子，该固态配合物在水溶液中稳定存在，在512 nm处有强的荧光发射峰。在所研究的9种能使该Zn-MOF配合物荧光信号发生猝灭的金属离子中，Fe3+的荧光猝灭效果最佳，猝灭百分数达90.9%，比荧光猝灭效果第二的Bi3+（猝灭百分数为59.2%）高出30%以上。Fe3+的荧光猝灭系数Ksv = 2.51 × 103 M-1，表明该Zn-MOF配合物是一种性能良好的检测Fe3+的荧光探针。研究结果及其应用对于促进生物系统的稳定和环境保护等方面的研究都具有重要意义。
关键词：配合物；荧光检测；金属离子
中图分类号：O657.34 文献标识码：A 文章编号：0258-3283（2017）
Application of Zn-MOF Coordination Compound in the Detection of Metal Ions of Aquous Solution ZHOU Yong*, YANG Yi, ZHU Xiao (Science and Technology Department, Changzhou Vocational Institute of Engineering, Changzhou 213164, China), Huaxue Shiji, 2017, 39(12)
Abstract：A new 2-D zinc metal-organic framework (Zn-MOF) is used as a kind of fluorescence sensor to detect the metal ions in aqueous solution, which is stable in aqueous solution and showed a strong photoluminescence (PL) emission maxima at 512 nm. Although the emission peak of Zn-MOF can be quenched by nine metal ions in aqueous solution, the ferric ion is the most effective quencher and can effectively quench the emission of Zn-MOF with a quench percentage (QP) of 90.9%, which is about 30% larger than that of the second best quencher (Bi3+ with a QP of 59.2%). The quenching constant (Ksv) of Fe3+ is 2.51×103 M-1, indicating that this framework can be employed as an excellent chemical sensor for identifying and quantifying Fe3+. The result and application is very important in the promoting the study of the stabilization of biological system and protection of the environment.
Key words: coordination compounds; fluorescence detection; metal ions
利用纯化除杂方法制备高品质四氯乙烯
陈宗艳1，吴孝兰*1，马骏1，肖历1，王涛2，陆惠懿2
（1. 国药集团化学试剂有限公司，上海 200002；2. 上海沃凯生物技术有限公司，上海 201507）
摘要：四氯乙烯是一种很重要的有机氯产品，由于其优良的性质，对四氯乙烯的质量要求也越来越高。主要对四氯乙烯的纯化工艺进行研究，探讨了萃取、吸附、精馏等方法分离纯化四氯乙烯的可行性，并对各参数进行了优化。结果显示，经过纯化，对叔戊基苯酚等杂质的含量明显降低，四氯乙烯的纯度得到了提升。
关键词：四氯乙烯；精馏；纯化
中图分类号：TQ225.2 文献标识码：A 文章编号： 0258-3283（2018）
Preparation of High Quality Tetrachloroethylene by Impurity Removal Method CHEN Zong-yan1, WU Xiao-lan*1, MAJun1, XIAO Li1, WANG Tao2, LU Hui-yi2 (1. Sinopharm Chemical Reagent Co., Ltd, Shanghai 200002, China; 2. Shanghai Our ChemBio-Technology Co., Ltd , Shanghai 201507, China), Huaxue Shiji, 2018, 40(1)
Abstract: Tetrachloroethylene is a kind of very important organochlorine products, due to its excellent properties. The quality of tetrachloroethylene has been required sharply. In this work, the purification process of tetrachloroethylene was investigated. The methods of extraction, adsorption, distillation separation and purification of tetrachloroethylene feasibility, and the parameters are optimized. Results show that the purity of tetrachloroethylene is improved significantly.
Key words: tetrachloroethylene; distillation; purification
过氧化氢法合成丁酮连氮的工艺研究
顾春思，王涛，田恒水*
(华东理工大学 化工学院，上海 200237)
摘要：采用甲酰胺催化丁酮(MEK)、氨气和过氧化氢合成丁酮连氮。通过考察氨气通入总量、氨气流速、反应时间、助催化剂种类、催化剂用量及初始水量对丁酮连氮合成反应的影响，得到最佳的合成工艺条件：氨气通入总量为V(NH3) ︰ n(MEK) = 18000(mL)︰1(mol)，氨气流速u(NH3) = 135 mL/min，反应时间t = 5 h，甲酰胺用量为n(甲酰胺)︰n(MEK) = 0.8，初始水量为n(初始水量)︰n(MEK)=1.6。在该工艺条件下，丁酮的转化率为91.87%，丁酮连氮的选择性和收率分别为94.78%和87.08%。
关键词：丁酮；过氧化氢；丁酮连氮；甲酰胺
中图分类号：TQ226.5 文献标识码：A 文章编号：0258-3283（2017）
Synthesis of Methyl Ethyl Ketazine by Hydrogen Peroxide Method GU Chun-si, WANG Tao, TIAN Heng-shui*（School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China）, Huaxue Shiji, 2017, 39(12)
Abstract：Methyl ethyl ketazine was synthetized by methyl ethyl ketone (MEK), ammonia and hydrogen peroxide, with formamide as catalyst. The effects of total ammonia, ammonia flow rate, reaction time, catalyst type, catalyst dosage and initial water content on the reaction were investigated. The best synthesis conditions were as follows: V(NH3) : n(MEK)= 18000(mL) : 1(mol), u(NH3) = 135 mL/min, t = 5 h, n(formamide ): n(MEK) = 0.8, n(initial water) : n(MEK) = 1.6. Under those synthesis conditions, the conversion of MEK was 91.87%, the selectivity and the yield of methyl ethyl ketazine were 94.87% and 87.08%, respectively.
Key words：methyl ethyl ketone; hydrogen peroxide; methyl ethyl ketazine; formamide
7-苄基-1, 7-二氮螺[4.4]壬烷-1-羧酸叔丁酯的合成
李永，李毅，李述敏，樊玲玲*
(贵州医科大学 药学院，贵州 贵阳 550004 )
摘要：以N-BOC-DL-脯氨酸甲酯为起始原料，先后经α-取代、NaBH4-CaCl2还原、IBX氧化、鲍奇还原胺化、环合等5步反应得到目标化合物，总产率为44.5%，其结构经1HNMR和MS确证。该方法合成路线短、条件温和、原料成本低、操作简单，比较适合较大规模的中间体制备。
关键词：N-BOC-DL-脯氨酸甲酯；鲍奇还原胺化；合成
中图分类号：O623.732 文献标识码：A 文章编号：0258-3283（2018）
Synthesis of Tert-butyl 7-benzyl-1,7-diazaspiro[4.4]nonane-1-carboxylate LI Yong, LI Yi, LI Shu -min, FANG Ling-ling *（College of Pharmacy, Guizhou Medical University, Guiyang 550004, China), Huaxue Shiji, 2018, 40(1)
Abstract: Tert-butyl7-benzyl-1,7-diazaspiro[4.4]nonane-1-carboxylate was synthesized in 44.5% overall yield from N-boc-DL-proline methyl ester via five steps including α-substitution, NaBH4-CaCl2 reduction, IBX oxidation, Borch reduction and cyclization. The structure of the target compound was confirmed by 1HNMR and HRMS. This synthetic routhas the advantages of mild conditions, easy operation, low cost and high yield, and is suitable for large-scale production.
Key words：N-Boc-DL-proline methyl ester; Borch reduction; synthesis
单取代/双取代氧化吲哚衍生物的合成研究
周鑫鑫*，周宁，刘长春
(江苏食品药品职业技术学院，江苏 淮安 223003)
摘要：氧化吲哚是药物分子和天然产物中较为常见的杂环化合物，具有很高的应用价值。应用不同的衍生方法能合成不同结构的衍生物，可制备高生物活性药物。以吲哚、靛红为原料，采用Lewis酸作催化剂，利用不同的反应条件选择性地合成了13个单取代氧化吲哚衍生物和13个双取代氧化吲哚衍生物，反应产率为77% ～ 98%，其结构经1HNMR表征。
关键词：吲哚；靛红；Lewis酸催化剂；氧化吲哚衍生物
中图分类号：O626 文献标识码：A 文章编号：0258-3283（2017）
Synthesis of Oxindole Derivatives with Monosubstituted and Disubstituted ZHOU Xin-xin*, ZHOU Ning, LIU Chang-chun (Jiangsu Food & Pharmaceutical Science College, Huaian 223003, China), Huaxue Shiji, 2017, 39(12)
Abstract：Monosubstituted and disubstitutedoxindole derivatives were synthesized separately from isatins and indoles in good to excellent yields by using different Lewis acid catalysts with the yield of 77% ~ 98%. The structures were confirmed by 1HNMR.
Key words：indole; isatin; Lewis acid catalyst; oxindole derivatives
